Methods of inhibiting angiogenesis and tumor growth, and...

A - Human Necessities – 61 – K

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A61K 31/56 (2006.01) A61K 31/565 (2006.01) A61K 31/57 (2006.01) A61K 31/575 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2180325

Methods for treating angiogenesis, tumors, and ocular hypertension with steroids are disclosed herein. The steroids have angiostatic activity with reduced glucocorticoid activity. A preferred steroid is6.alpha.,9.alpha.-fluoro-11.beta.,17-dihydroxy-16.alpha.-methyl-pregna-1,4- diene-3-one-17-carboxylic acid.

La présente invention concerne des procédés de traitement par stéroïdes de l'angiogenèse, des tumeurs, et de l'hypertension oculaire. Ces stéroïdes sont caractérisés par un effet angiostatique et une faible activité glucocorticoïde. Un stéroïde préféré est l'acide 6.alpha.,9.alpha.-fluoro-11.beta.,17-dihydroxy-16.alpha.-méthyl-prégna-1,4-diène-3-one-17-carboxylique.

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