Methods of inhibiting conditions associated with neuropeptide y

A - Human Necessities – 61 – K

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A61K 31/40 (2006.01) A61K 31/35 (2006.01) A61K 31/4025 (2006.01) A61K 31/445 (2006.01) A61K 31/4535 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2200990

A method of inhibiting a physiological disorder associated with an excess of neuropeptide Y or its symptoms comprising administering to a human in need thereof an effective amount of a compound having formula (I), wherein R1 and R3 are independently hydrogen, -CH3, (a) or (b), wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneimino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.

La présente invention concerne un procédé d'inhibition d'un trouble physiologique lié à un excès de neuropeptide Y ou d'inhibition de ses symptômes. Ce procédé consiste à administrer à un humain en ayant besoin une quantité suffisante d'un composé représenté par la formule générale (I), ou l'un de ses sels acceptables du point de vue pharmaceutique. Dans cette formule, R?1¿ et R?3¿ sont indépendamment hydrogène, -CH¿3?, (a) ou (b), Ar étant un phényle éventuellement substitué; R?2¿ appartient au groupe formé par pyrrolidine, hexaméthylénimino et pipéridine.

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