A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/55 (2006.01)
Patent
CA 2198114
A method of inhibiting demyelinating or dysmyelinating diseases or their symptoms comprising administering to a human in need thereof an effective amount of a compound having formula (I) wherein R1 and R3 are independently hydrogen, -CH3, (a) or (b), wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneimino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.
L'invention concerne un procédé pour combattre les démyélinations et les dysmyélinations pathologiques ou leurs symptômes, consistant à administrer à un patient une quantité suffisante pour être efficace d'un composé de la formule (I). Dans cette formule, R?1¿ et R?3¿ sont d'une manière indépendante un hydrogène, un groupe -CH¿3?, (a) ou (b), où Ar est un phényle, éventuellement substitué; R?2¿ est choisi parmi les groupes pyrrolidine, hexaméthylène-imino et pipéridino. L'invention concerne également des sels et des solvates de ces composés acceptables sur le plan pharmaceutique.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
LandOfFree
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