Methods of inhibiting effects of il-6

Details Methods of inhibiting effects of il-6 Methods of inhibiting effects of il-6

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/4535 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2212232

A method of inhibiting the effects of IL-6 comprising administering to a human in need thereof an effective amount of a compound having formula (I) wherein R1 and R3 are independently hydrogen, -CH3, (a), or (b), wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneimino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.

Procédé d'inhibition des effets d'IL-6 consistant à administrer à l'homme en ayant besoin une quantité efficace d'un composé de formule (I) dans laquelle R?1¿ et R?3¿ représentent indépendamment hydrogène, -CH¿3?, (a) ou (b) où Ar représente phényle éventuellement substitué; R?2¿ est sélectionné dans le groupe constitué par pyrrolidine, hexaméthylèneimino et piperidino; ou un sel pharmaceutiquement acceptable de son solvat.

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