Methods of inhibiting kinases

Details Methods of inhibiting kinases Methods of inhibiting kinases

A - Human Necessities

61

K

A61K 31/435 (2006.01) A61K 31/443 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61K 31/4985 (2006.01) A61K 31/5377 (2006.01) A61K 31/551 (2006.01) A61P 7/12 (2006.01) A61P 11/02 (2006.01) A61P 17/00 (2006.01) A61P 19/00 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2436487

The present invention provides methods of inhibiting JAK involving the use of a group of compounds based either upon a 2-amino-6-carba-disubstituted pyrazine scaffold or a 2-amino-6-carba-disubstituted pyridine scaffold. The invention also provides methods of treating JAK-associated disease states.

La présente invention concerne des procédés d'inhibition de kinases de Janus (JAK) qui consistent en l'utilisation d'un groupe de composés soit à base d'un squelette de 2-amino-6-carba-disubstitué pyrazine ou d'un squelette de 2-amino-6-carba-disubstitué pyridine. L'invention concerne également des procédés de traitement de conditions pathologiques associées aux kinases de Janus (JAK).

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