A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) A61K 31/56 (2006.01)
Patent
CA 2242245
This invention provides methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a cardiac glycoside or aglycone derivative. Leaderless proteins include FGF-1, FGF-2, IL-1.alpha., IL- 1.beta. and factor XIIIa. These methods are useful in treatment of conditions, including tumors and diabetes.
Cette invention concerne des procédés d'inhibition de l'exportation d'une protéine sans séquence de tête à partir d'une cellule consistant à mettre la cellule en contact avec un dérivé glycoside ou aglyone cardiaque. Les protéines sans séquence de tête comprennent FGF-1, FGF-2, IL-1.alpha., IL-1.beta. et le facteur XIIIa. Ces procédés sont utiles dans le traitement d'états pathologiques, notamment de tumeurs et du diabète.
Gowling Lafleur Henderson Llp
The Scripps Research Institute
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