Methods of inhibiting myeloperoxidase activity

Details Methods of inhibiting myeloperoxidase activity Methods of inhibiting myeloperoxidase activity

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/40 (2006.01) A61K 31/4535 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2138513

A method of inhibiting myeloperoxidase activity or a physiological condition associated with an excess thereof, comprising administering to a human in need thereof an effective amount of a compound having the formula Image (I) wherein R1 and R3 are independently hydrogen, Image Image -CH3, , or , wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneamino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.

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