C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A61K 31/00 (2006.01) A61K 31/03 (2006.01) A61K 31/075 (2006.01) A61K 31/09 (2006.01) A61K 31/136 (2006.01) A61K 31/195 (2006.01) A61K 31/196 (2006.01) A61K 31/235 (2006.01) A61K 31/56 (2006.01) A61K 31/565 (2006.01) A61K 31/585 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 5/10 (2006.01) C07K 5/103 (2006.01) C07K 5/107 (2006.01) C07K 5/113 (2006.01) C07K 7/06 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2380007
Methods of inhibiting osteoclastogenesis and the activity of osteoclasts are disclosed. Methods of treating patients who have diseases characterized bone loss are disclosed. According to the methods, an amount of a TRANCE/RANK inhibitor effective to inhibit osteoclastogenesis is administered to the patient. Pharmaceutical compositions which comprise TRANCE/RANK inhibitor in an amount effective to inhibit osteoclastogenesis. Methods of modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems in an individual are disclosed. The methods comprise the step of administering to the individual an amount of a TRANCE/RANK inhibitor effective to modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems.
L'invention concerne des procédés permettant d'inhiber l'ostéoclastogénèse et l'activité des ostéoclastes, ainsi que des procédés de traitement de patients souffrant de maladies caractérisées par une perte osseuse. On administre une dose d'un inhibiteur TRANCE/RANK efficace pour inhiber l'ostéoclastogénèse. L'invention traite de compositions pharmaceutiques renfermant l'inhibiteur TRANCE/RANK en dose efficace pour inhiber l'ostéoclastogénèse, ainsi que de procédés de modulation de la maturation de cellule dendritique, de la prolifération de cellule T et/ou de systèmes récepteurs de CD40 chez un individu. Les procédés consistent à administrer au patient une dose d'un inhibiteur TRANCE/RANK efficace pour moduler la maturation de cellule dendritique, la prolifération de cellule T et/ou les systèmes récepteurs de CD40.
Greene Mark I.
Kinosaki Masahiko
Murali Ramachandran
Robic
The Trustees Of The University Of Pennsylvania
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