Methods of inhibiting osteoclastogenesis

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/12 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2380009

Methods of inhibiting osteoclastogenesis and the activity of osteoclasts are disclosed. Methods of treating patients who have diseases characterized bone loss are disclosed. The present invention also provides peptides and peptide analogues designed from a binding loop of a member of the tumor necrosis factor receptor (TNF-R) superfamily. According to the methods, an amount of an inhibitor effective to inhibit osteoclastogenesis is administered to the patient. Methods of modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems in an individual are disclosed. The methods comprise the step of administering to the individual an amount of an inhibitor effective to modulating dendriticall maturation, T cell proliferation, and/or CD40 receptor systems.

L'invention concerne des méthodes destinées à inhiber l'ostéoclastogenèse et l'activité des ostéoclastes. L'invention concerne également des méthodes de traitement de patients atteints de maladies caractérisées par une perte osseuse. La présente invention concerne en outre des peptides et des analogues de peptides mis au point à partir d'une boucle de fixation d'un élément de la superfamille de récepteurs de facteur de nécrose tumorale (TNF-R). Selon ces méthodes, on administre au patient une quantité d'inhibiteur efficace pour inhiber l'ostéoclastogenèse. L'invention concerne également des méthodes de modulation de la maturation des cellules dendritiques, de la prolifération des lymphocytes T, et/ou des systèmes récepteurs CD40 chez un individu. Ces méthodes consistent à administrer à l'individu une quantité d'inhibiteur efficace pour moduler la maturation des cellules dendritiques, la prolifération des lymphocytes T, et/ou les systèmes récepteurs CD40.

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