Methods of inhibiting plasminogen activator inhibitor 1

Details Methods of inhibiting plasminogen activator inhibitor 1 Methods of inhibiting plasminogen activator inhibitor 1

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/38 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/4535 (2006.01)

Patent

CA 2234404

A method of inhibiting plasminogen activator inhibitor 1 comprising administering to a human in need thereof an effective amount of a compound having formula (I), wherein R1 and R3 are independently hydrogen, -CH3, (a) or (b), wherein Ar is optionally s ubstituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneimino, and piperidino; or a pharmaceutically acceptable salt or solvate thereof.

L'invention porte sur un procédé de l'inhibiteur 1 d'activateur de plasminogène, consistant à administrer à une personne qui en a besoin une dose efficace d'un composé représenté par la formule générale (I) dans laquelle R?1¿ et R?3¿ représentent indépendamment hydrogène, -CH¿3?, (a) ou (b), et Ar pouvant éventuellement être par phényle substitué; R?2¿ est sélectionné dans un groupe com posé de pyrrolidine, hexaméthylènimino et pipéridino; ou sur un sel ou solvate de ce composé, admis en pharmacie.

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