C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 251/80 (2006.01) A61K 31/15 (2006.01) A61P 9/10 (2006.01) A61P 25/28 (2006.01) C07D 207/323 (2006.01) C07D 211/16 (2006.01) C07D 231/12 (2006.01) C07D 295/192 (2006.01) C07D 307/52 (2006.01) C07D 333/22 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2692801
Disclosed are methods of inhibiting, regulating, and/or modulating the formation of soluble, globular, non-fibrillar, neurotoxic amyloid .beta.1-42 oligomers from amyloid .beta.1-42 monomers using acylhydrazidecompounds. Also disclosed are methods of treating a patient suffering from diseases associated with the formation of soluble, globular, non-fibrillar, neurotoxic amyloid .beta.1-42 oligomers using acylhydrazidecompounds.
La présente invention concerne des procédés d'inhibition, de régulation et/ou de modulation de la formation d'oligomères d'amyloïde ß1-42 neurotoxiques non-fibrillaires globulaires solubles, à partir de monomères d'amyloïde ß1-42, au moyen de composés d'acylhydrazide. La présente invention concerne également des procédés de traitement d'un patient atteint de maladies associées à la formation d'oligomères d'amyloïde ß1-42 neurotoxiques non fibrillaires globulaires solubles, au moyen de composés d'acylhydrazide.
Bhagat Nikhil
Goure William F.
Krafft Grant A.
Look Gary Charles
Polozov Alexandre Mikhaylovich
Acumen Pharmaceuticals Inc.
Ridout & Maybee Llp
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