Methods of inhibiting thrombin

Details Methods of inhibiting thrombin Methods of inhibiting thrombin

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/4535 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2138493

A method of inhibiting thrombin and its attending diseases and conditions comprising administering to a human in need of treatment an effective amount of a compound having the formula Image (I) wherein R1 and R3 are independently hydrogen, -CH3, Image , or Image , wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidino, hexamethyleneamino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.

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