C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/495 (2006.01) C12N 5/09 (2010.01) A61K 31/4439 (2006.01) A61K 31/7088 (2006.01) A61K 35/54 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/475 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) G01N 33/48 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2658786
The invention provides compositions comprising one or more isolated factors from a microenvironment of human embryonic stem cells (hESCs), including, but not limited to, Lefty and inhibitors of Nodal. The invention also provides methods of utilizing factors derived from human embryonic stem cells (hESC) and their microenvironment to treat and prevent tumor formation and progression and to inhibit tumor cell aggressiveness. The invention further provides methods of inhibiting tumor cell growth and/or treating aggressive tumors in a mammal comprising administering to the mammal, having at least one tumor cell present in its body, an effective amount of an inhibitor of Nodal activity.
L'invention concerne des compositions comprenant un ou plusieurs facteurs isolés provenant d'un microenvironnement de cellules souches embryonnaires humaines (hESC), comprenant, mais sans y être limités, Lefty et les inhibiteurs de Nodal. L'invention concerne également des procédés d'utilisation de facteurs issus de cellules souches embryonnaires humaines (hESC) et de leur microenvironnement pour traiter et prévenir la formation et la progression de tumeurs et pour inhiber l'agressivité des cellules tumorales. L'invention concerne en outre des procédés d'inhibition de la croissance des cellules tumorales et/ou de traitement des tumeurs agressives chez un mammifère, comprenant l'administration à un mammifère ayant au moins une cellule tumorale présente dans le corps d'une quantité efficace d'un inhibiteur de l'activité de Nodal.
Hendrix Mary Jessica
Postovit Lynne-Maire
Seftor Elisabeth Ann
Seftor Richard Edward Barnet
Children's Memorial Hospital
Mbm Intellectual Property Law Llp
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