Methods of inhibiting viral infection

Details Methods of inhibiting viral infection Methods of inhibiting viral infection

C - Chemistry, Metallurgy

07

D

C07D 215/46 (2006.01) A61K 31/4706 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2701492

Compounds, pharmaceutical compositions and methods of inhibiting viral infection in a mammal in need of same, are provided, which employ compounds of formula (I); wherein each X is independently H or an electrodonating group, each Y is independently H, alkyl of 1 - 4 carbon atoms, hydroxy, alkoxy or methylene and wherein Substituent Z is a di-or-tri akly amino, or alkyl di or tri amino, optionally substituted with a halogen moiety. This family of compounds, designated FGI-104 herein, inhibits viral infection therapeutically and prophylactically.

L'invention concerne des composés, des compositions pharmaceutiques et des procédés d'inhibition d'une infection virale chez un mammifère en ayant besoin. Ceux-ci font appel à des composés de la formule (I), dans laquelle chaque X représente indépendamment un atome H ou un groupe électrodonneur, chaque Y représente indépendamment un atome H, un groupe alkyle de 1 à 4 atomes de carbone, hydroxy, alcoxy ou méthylène et dans laquelle le substituant Z est un groupe di- ou trialkylamino, ou un groupe alkyle di- ou triamino, éventuellement substitué par une fraction halogène. Cette famille de composés, désignée par FGI-104, inhibe une infection virale de manière thérapeutique ou prophylactique.

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