Methods of inhibiting viral infection

Details Methods of inhibiting viral infection Methods of inhibiting viral infection

A - Human Necessities

61

K

A61K 31/4706 (2006.01) A61K 31/381 (2006.01) A61K 31/4178 (2006.01) A61P 31/12 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2702248

A method of inhibiting viral infection in a mammal in need of same, includes administering an effective amount of at least one of the compounds of FGI- 103 which are represented by 273, 365 and 510 either prophylactically to prevent viral infection, or therapeutically following viral infection. These compounds appear to selectively inhibit Caspase 8 as a method of preventing infective viral particle release. They can be administered IV, IP, orally or via other conventional administration routes. The compounds are highly effective, requiring relatively low dosages on the order of 1 ng/kg - 200 mg/kg of body weight.

L'invention concerne un procédé visant à inhiber une infection virale chez un mammifère nécessitant un tel traitement, et qui comprend l'administration d'une quantité efficace d'au moins un des composés de FGI- 103 qui sont représentés par 273, 365 et 510, soit à des fins prophylactiques pour prévenir une infection virale, soit à des fins thérapeutiques après une infection virale. Ces composés, qui inhibent sélectivement la caspase 8, permettent de prévenir la libération de particules virales infectieuses. Ils peuvent être administrés par voie orale, I.V., I.P. ou par d'autres voies d'administration classiques. Ces composés sont très efficaces et nécessitent des dosages relativement faibles, de l'ordre de 1 ng/kg - 200 mg/kg de poids corporel.

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