A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 36/51 (2006.01) A61K 31/216 (2006.01) A61K 31/353 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) B01D 11/02 (2006.01) B01D 15/12 (2006.01)
Patent
CA 2427661
Assay-guided affinity fractionation and reverse phase high pressure liquid chromatography (HPLC) methodology to isolate, test and characterize the most active water-soluble ingredients within Cat's Claw, or Uncaria tomentos. These components appear to account for the majority of the amyloid or A.beta. fibrillogenesis inhibitory activity. Individual fractions and/or compounds as isolated by HPLC are tested in relevant in vitro and/or animal models, and found to consistently demonstrate inhibition of amyloid or A.beta. fibrillogenesis. Related extraction methods are disclosed.
L'invention concerne une méthodologie de chromatographie liquide haute pression en phase inverse et de fractionnement d'affinité guidé par dosage, laquelle sert à isoler, essayer et caractériser les ingrédients hydrosolubles les plus actifs contenus dans la griffe de chat ou Uncaria tomentosa. Ces composants semblent posséder la majeure partie de l'activité inhibitrice de la fibrillogenèse A.beta. ou amyloïde. On a testé des fractions individuelles et/ou composés, tels ceux isolés à l'aide de la chromatographie ci-dessus, dans des modèles in vitro et/ou animaux, et on a trouvé que ces fractions et/ou composés démontraient immanquablement une inhibition de la fibrillogenèse A.beta. ou amyloïde. L'invention concerne également des procédés d'extraction associés.
Castillo Gerardo
Choi Paula Y.
Nguyen Beth
Snow Alan D.
Proteotech Inc.
Smart & Biggar
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