A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/19 (2006.01) A61K 31/47 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2543611
This invention relates to methods for lowering lipid levels in mammals using compounds that inhibit advanced glycation endproducts (AGEs), LR-9, LR-74 and LR-90. These compounds, which inhibit non-enzymatic protein glycation, also inhibit the formation of advanced lipoxidation endproducts (ALEs) on target proteins by trapping intermediates in glycoxidation and lipoxidation and inhibiting oxidation reactions important in the formation of AGEs and ALEs.
L'invention concerne des méthodes d'abaissement des taux de lipides chez des mammifères, dans lesquelles on utilise des composés qui inhibent les produits terminaux de glycation avancée (AGEs), LR-9, LR-74 et LR-90. Ces composés, qui inhibent la glycation protéique non enzymatique, inhibent également la formation de produits terminaux de lipoxydation (ALEs) sur des protéines cibles, par piégeage d'intermédiaires dans la glycoxydation et la lopoxydation et par inhibition des réactions d'oxydation dans la formation d'AGEs et d'ALEs.
Figarola James Lester
Rahbar Samuel
City Of Hope
Osler Hoskin & Harcourt Llp
LandOfFree
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