Methods of maintaining teeth and oral bone

Details Methods of maintaining teeth and oral bone Methods of maintaining teeth and oral bone

A - Human Necessities

61

K

A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/445 (2006.01) A61K 31/4535 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2198108

A method of inhibiting maintaining teeth and oral bone comprising administering to a human in need thereof an effective amount of a compound having formula (I), wherein R1 and R3 are independently hydrogen, -CH3, (a) or (b), wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneimino, and piperidino; or a pharmaceutically acceptable salt or solvate thereof.

L'invention concerne un procédé pour conserver en état les os alvéolaire et maxilaires et les dents, consistant à administrer à un être humain à traiter, une dose efficace d'un composé ayant la formule (I). Dans cette formule, R?1¿ et R?3¿ représentent indépendamment un hydrogène, un groupe -CH¿3?, (a) ou (b), où Ar est un phényle éventuellement substitué; R?2¿ est choisi dans le groupe constitué de pyrrolidine, hexaméthylèneimino et pipéridino. L'invention concerne également un sel ou solvate de ces composés acceptable sur le plan pharmaceutique.

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