Methods of making...

Details Methods of making... Methods of making...

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/415 (2006.01)

Patent

CA 2517002

6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4- carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9- phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension.

L'invention concerne le 6-[(4,5-dihydro-1H-imidazol-2-yl)amino-]-7-méthyl-1H-benzimidazole-4-carbonitrile sensiblement exempt de 2,3,7-triamino-4,6-diméthyl-1,9-phénazinedicarbonitrile, et son sel de monoacétate anhydre, qui sont utiles dans le traitement de troubles à médiation par alpha-2 tels que l'hypertension oculaire.

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