Methods of making concentrated fibrinogen containing...

A - Human Necessities – 61 – L

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A61L 24/10 (2006.01) A61K 38/36 (2006.01) A61K 38/48 (2006.01) A61M 35/00 (2006.01) A61P 7/04 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2682405

The present invention is drawn to concentrated fibrinogen compositions and associate methods and use thereof. The concentrated fibrinogen compositions can be produced by adding a sufficient amount of a cationic agent, such as protamine, to a fibrinogen containing fluid to cause the fibrinogen to form a fibrinogen precipitate; collecting the fibrinogen precipitate by a collection means, such as centrifugation; and suspending or solubilizing the fibrinogen precipitate in a liquid vehicle to form a concentrated fibrinogen composition. The concentrated fibrinogen compositions can be incorporated into systems for making fibrin glues and be used in treating wounds.

L'invention concerne des compositions de fibrinogène concentré, et des procédés associés, et leur utilisation. Les compositions de fibrinogène concentré peuvent être produites en ajoutant une quantité suffisante d'un agent cationique, tel que la protamine, à un fluide contenant du fibrinogène, pour amener le fibrinogène à former un précipité de fibrinogène; en collectant le précipité de fibrinogène par des moyens de collecte, tels que la centrifugation; et en suspendant ou en solubilisant le précipité de fibrinogène dans un véhicule liquide pour former une composition de fibrinogène concentré. Les compositions de fibrinogène concentré peuvent être incorporées dans des systèmes pour réaliser des colles de fibrine, et peuvent être utilisées dans des traitements de plaie.

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