Methods of making viral particles having a modified cell...

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/86 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 7/04 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2494245

The present invention relates to a method for packaging viral particles such that one or more peptides on the surface of the virus particle are derived from the packaging cell. By incorporating certain peptides it is possible to target viral particles to specific cell types. Such a system is of use, for example, in gene therapy treatments.

L'invention concerne une méthode permettant d'encapsider des particules virales de façon qu'un ou plusieurs peptides présents sur la surface des particules virales dérivent de la cellule d'encapsidation. L'incorporation de certains peptides permet aux particules virales de cibler des types cellulaires spécifiques. Ce système trouve son application, par exemple, en thérapie génique.

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