Methods of modulating immune coagulation

Details Methods of modulating immune coagulation Methods of modulating immune coagulation

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 31/70 (2006.01) A61K 39/395 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01) C12N 15/55 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01) G01N 33/86 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2289979

Methods for mediating immune coagulation using novel antibodies and compounds are described. A protein Fgl2 having direct prothrombinase activity has been identified. Inhibitors of Fgl2 are useful in preventing and treating diseases which require a reduction in immune coagulation including bacterial and viral infections, allograft and xenograft rejection, glomerulonephritis, cancer, a number of gastrointestinal diseases and fetal loss.

L'invention concerne de nouvelles méthodes permettant d'induire une coagulation immune au moyen de nouveaux anti-corps et composés. On a identifié une protéine Fgl2 ayant une activité prothrombinase directe. Des inhibiteurs de Fgl2 sont utiles dans la prévention et dans le traitement de maladies nécessitant une réduction de la coagulation immune notamment dans les affections bactériennes et virales, le rejet d'allogreffes et d'hétérogreffes, la glomérulonéphrite, le cancer, un certain nombre de maladies gastrointestinales et la perte du foetus.

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