C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01)
Patent
CA 2558371
The invention relates to methods of modulating immune responses in a subject, such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Thl and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them.
La présente invention a trait à des procédés de modulation de réponses immunitaires chez un sujet, tel que par l'administration au sujet d'agents de modulation de l'activité de tim-1, tim-2 ou tim-4, ou de modulation de l'interaction physique entre le tim-1 et le tim-4 ou entre le tim-2 et un ligand de tim-2. Des réponses immunitaires comprennent, mais de manière non exclusive, des troubles autoimmuns, la tolérance à la transplantation, et des réponses et troubles liés à Th1 et Th2. L'invention a également trait à de nouveaux dosages pour l'identification d'agents de modulation de l'interaction physique entre le tim-1 et le tim-4. L'invention a trait en outre à de nouveaux polypeptides de tim-4 solubles et à des acides nucléiques codant pour de tels polypeptides.
Chakravarti Sumone
Kuchroo Vijay K.
Meyers Jennifer
Strom Terry
Zheng Xin Xiao
Beth Israel Deaconess Medical Center Inc.
Smart & Biggar
The Brigham And Women's Hospital Inc.
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