Methods of modulating intracellular degradation rates of toxins

Details Methods of modulating intracellular degradation rates of toxins Methods of modulating intracellular degradation rates of toxins

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 38/48 (2006.01) A61K 45/06 (2006.01) A61P 21/02 (2006.01) A61P 29/00 (2006.01) A61P 39/02 (2006.01) C07K 14/195 (2006.01) C07K 14/33 (2006.01)

Patent

CA 2571982

The present invention provides for methods of modulating the degradation rate of a toxin in a cell thereby modulating the half-life of the toxin. Particularly, the invention features methods of modulating the degradation rate of a toxin by modulating fusion between a lysosome and an endosome that carries the toxin in the cell.

L'invention concerne des procédés de modulation du taux de dégradation d'une toxine dans une cellule, ce qui permet de moduler la demi-vie de la toxine. L'invention concerne en particulier des procédés de modulation du taux de dégradation d'une toxine par modulation de la fusion entre un lysosome et un endosome qui porte la toxine dans la cellule.

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