Methods of modulating lipid metabolism and storage

Details Methods of modulating lipid metabolism and storage Methods of modulating lipid metabolism and storage

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 3/00 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2327260

Anti-hedgehog antibodies directed at blocking the binding of hedgehog to its receptor patched-1, will impair lipid metabolism and storage. This invention presents methods for the treatment of a variety of lipid metabolism and lipid storage disorders, aberrant apolipoprotein expression, atherosclerosis and other lipid associated disorders using lipid modulators such as hedgehog antagonists or hedgehog agonists.

Des anticorps dirigés contre les signaux Hedgehog servant à bloquer la fixation du signal Hedgehog sur son récepteur patched-1, portent atteinte au métabolisme et au stockage lipidiques. La présente invention concerne des méthodes de traitement d'une variété de troubles du métabolisme lipidique et du stockage des lipides, de l'expression aberrante des apolipoprotéines, de l'athérosclérose ainsi que de divers troubles liés aux lipides à l'aide de modulateurs lipidiques tels que des antagonistes des signaux Hedgehog et des agonistes des signaux Hedgehog.

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