Methods of modulating melanin synthesis

Details Methods of modulating melanin synthesis Methods of modulating melanin synthesis

A - Human Necessities

61

K

A61K 38/44 (2006.01) A61K 8/11 (2006.01) A61K 8/14 (2006.01) A61K 8/60 (2006.01) A61K 8/64 (2006.01) A61K 31/70 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 48/00 (2006.01) A61Q 5/08 (2006.01) A61Q 19/02 (2006.01) C12N 15/88 (2006.01) C12Q 1/26 (2006.01) C12Q 1/48 (2006.01) D06L 3/00 (2006.01)

Patent

CA 2250000

Methods are described whereby vertebrate skin, hair, wool or fur may be lightened, or darkened, in color by administration of a substance, e.g., peptide, antibody, antibody fragment or DNA sequence encoding a peptide, that modulates the protein kinase C-beta-mediated activation of tyrosinase, the rate-limiting enzyme in melanogenesis.

Techniques permettant d'éclaircir ou d'assombrir la peau, les cheveux, la laine ou la fourrure de vertébrés par l'administration d'une substance, par exemple un peptide, un anticorps, un fragment d'anticorps ou une séquence d'ADN codant un peptide, qui module l'activation, induite par la protéine kinase C-bêta, de la tyrosinase, enzyme qui limite le taux de mélanogénèse.

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