C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/37 (2006.01) C12Q 1/34 (2006.01) C12Q 1/48 (2006.01)
Patent
CA 2484013
The present invention provides methods for identifying agents that modulate a level or an activity of a mitochondrial NAD-dependent deacetylase polypeptide, as well as agents identified by the methods. The invention further provides methods of modulating mitochondrial NAD-dependent deacetylase activity in a cell. The invention further provides methods of modulating mitochondrial function by modulating the activity of mitochondrial NAD-dependent deacetylase.
La présente invention concerne des méthodes d'identification d'agents qui modulent un niveau ou une activité d'un polypeptide de la désacétylase mitochondriale NAD-dépendante, ainsi que des agents identifiés grâce à ces méthodes. L'invention concerne également des méthodes de modulation de l'activité de la désacétylase mitochondriale NAD-dépendante dans une cellule. L'invention concerne également des méthodes de modulation de la fonction mitochondriale par modulation de l'activité de la désacétylase mitochondriale NAD-dépendante.
North Brian J.
Schwer Bjoern
Verdin Eric
Fetherstonhaugh & Co.
The Regents Of The University Of California
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