Methods of modulating neurotrophin-mediated activity

A - Human Necessities – 61 – K

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A61K 31/513 (2006.01) A61K 31/4155 (2006.01) A61K 31/4178 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2556159

Disclosed are compositions which modulate the interaction of nerve growth factor and brain-derived neurotrophic factor with neurotrophic receptors, comprising contacting cells expressing a neurotrophin receptor with an effective amount of a compound of Formulas 1-6. Also disclosed are methods of using the compositions of the invention for the treatment of pain, inflammatory disorder and neurological disorder in subject in need.

La présente invention a trait à des compositions de modulation de l'interaction du facteur de croissance nerveuse et du facteur neurotrophique cérébral avec des récepteurs neurotrophiques. L'invention a également trait à des procédés d'utilisation de compositions de l'invention, comprenant des procédés d'administration.

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