Methods of modulating neurotrophin-mediated activity

Details Methods of modulating neurotrophin-mediated activity Methods of modulating neurotrophin-mediated activity

C - Chemistry, Metallurgy

07

D

C07D 221/06 (2006.01) A61K 31/473 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07D 209/90 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2622571

Disclosed are compounds and pharmaceutically acceptable compositions thereof which modulate the interaction between nerve growth factor and precursors thereof and neurotrophm receptors and treat disease conditions mediated therefrom such as pam, inflammatory disorders and neurological disorders Also disclosed are methods of using the compounds and compositions of the invention, including methods of administration The compounds have the following structural formula wherein m and n are independently 0 or 1 , x and y are independently 0 or 1, provided that n and y are not 0 at the same time, and the substituents R1-R5, Rloand R11 are further defined in the Formula (I).

L'invention concerne des compositions qui modulent l'interaction entre le facteur de croissance des nerfs et ses précurseurs et les récepteurs neurotrophiques. L'invention concerne également des méthodes destinées à l'utilisation de ces compositions, ainsi que des méthodes d'administration associées.

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