Methods of modulating neurotrophin-mediated activity

Details Methods of modulating neurotrophin-mediated activity Methods of modulating neurotrophin-mediated activity

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4375 (2006.01)

Patent

CA 2622574

The current application discloses methods of modulating the interaction of nerve growth factor, or precursors thereof, with neurotrophin receptors by contacting cells expressing a neurotrophin receptor with a benzo-phenantroline core structure compound. The compounds involved in these methods are the ones of formulae (16-22). Also claimed and disclosed are specific compounds of formulae (16-21),of which formulae (16) and (21) are herein given as a chemical core type-structure of the disclosed compounds.

La présente invention concerne des compositions qui modulent l'interaction avec le facteur de croissance nerveuse et des précurseurs de celui-ci au moyen de récepteurs neurotrophiques. Cette invention concerne également des méthodes d'utilisation des compositions de cette invention, y compris des méthodes d'administration.

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