G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/48 (2006.01) A61K 31/17 (2006.01) A61K 31/42 (2006.01) A61K 31/433 (2006.01) A61K 31/44 (2006.01) A61P 3/04 (2006.01) A61P 25/18 (2006.01)
Patent
CA 2592158
The present invention provides methods for identifying compounds useful in modulating a7 nicotinic acetylcholine receptors. The invention also provides compounds that prevent, suppress or inhibit desensitization of an a7 nicotinic acetylcholine receptor, and which resensitize such receptors. Pharmaceutical compositions, and methods of treatment, particularly in regard of neurological diseases are also described.
La présente invention porte sur des méthodes d'identification de composés utiles dans la modulation des récepteurs d'acétylcholine a7 nicotiniques. L'invention porte également sur des composés qui permettent de prévenir, supprimer ou inhiber la désensibilisation d'un récepteur d'acétylcholine a7 nicotinique et qui resensibilisent ces récepteurs. L'invention porte également sur des compositions pharmaceutiques et sur des méthodes de traitement concernant notamment des maladies neurologiques.
Groppi Vincent Edward Jr.
Hurst Raymond Stuart
Piotrowski David Walter
Pfizer Products Inc.
Smart & Biggar
LandOfFree
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