Methods of modulating tubulin deacetylase activity

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/34 (2006.01) A61K 31/7056 (2006.01) A61K 45/00 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2485988

The present invention provides methods for identifying agents that modulate a level or an activity of tubulin deacetylase polypeptide, as well as agents identified by the methods. The invention further provides methods of modulating tubulin deacetylase activity in a cell. The invention further provides methods of modulating cellular proliferation by modulating the activity of tubulin deacetylase.

La présente invention concerne des procédés d'identification d'agents qui modulent un niveau ou une activité d'un polypeptide de tubuline désacétylase. La présente invention traite également d'agents identifiés par ces procédés. L'invention concerne aussi des procédés de modulation de l'activité de la tubuline désacétylase dans une cellule. L'invention a aussi pour objet des procédés de modulation de la prolifération cellulaire par la modulation de l'activité de la tubuline désacétylase.

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