Methods of monitoring the modulation of the kinase activity...

Details Methods of monitoring the modulation of the kinase activity... Methods of monitoring the modulation of the kinase activity...

G - Physics

01

N

G01N 33/68 (2006.01) G01N 33/74 (2006.01) G01N 33/84 (2006.01)

Patent

CA 2720888

The present invention relates generally to methods of in vitro diagnostics, in particular the use of a compound selected from the group consisting of fibroblast growth factor 23 (FGF23), inorganic phosphorus (P), the product of inorganic phosphorus and total calcium (P x tCa), osteopontin (OPN) and parathyroid hormone (PTH) as biomarker. Said biomarkers can be used to monitor the modulation of fibroblast growth factor receptor (FGFR) kinase activity, in particular its inhibition, and/or the occurrence of secondary effects of FGFR inhibition. The invention further provides methods and kits relating to these uses.

La présente invention concerne, de façon générale, des procédés de diagnostic in vitro et, en particulier, l'utilisation, en tant que biomarqueur, d'un composé choisi dans le groupe constitué du facteur de croissance des fibroblastes 23 (FGF23), du phosphore inorganique (P), du produit du phosphore inorganique et du calcium total (P x CaT), de l'ostéopontine (OPN) et de l'hormone parathyroïdienne (HPT). Lesdits biomarqueurs peuvent être utilisés pour le suivi de la modulation de l'activité kinase du récepteur du facteur de croissance des fibroblastes (FGFR), en particulier de son inhibition, et/ou de la survenue d'effets secondaires associés à l'inhibition du FGFR. L'invention concerne encore des procédés et nécessaires associés à ces utilisations.

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