Methods of neuroprotection by cyclin-dependent kinase...

Details Methods of neuroprotection by cyclin-dependent kinase... Methods of neuroprotection by cyclin-dependent kinase...

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61P 25/28 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2672898

The present invention relates to methods of suppressing neuronal death, such as is observed with ischemia-related diseases and disorders, including neuronal and cardiac conditions arizing from a sudden loss of oxygen and/or energy loss, and degenerative diseases, such as Alzheimer's disease to name just one. The methods involve the use of inhibitors that act primarily in a simultaneous manner on the cyclin- dependent kinases, CDK4 and CDK6.

L'invention concerne des procédés de suppression de la mort neuronale, telle qu'observée avec des maladies et des troubles liés à l'ischémie, comprenant des affections neuronales et cardiaques provenant d'une perte soudaine d'oxygène et/ou d'une perte d'énergie, et des maladies dégénératives, telles que la maladie d'Alzheimer pour n'en nommer qu'une. Les procédés impliquent l'utilisation des inhibiteurs qui agissent principalement d'une manière simultanée sur es kinases cycline-dépendantes, CDK4 et CDK6.

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