Methods of oligosaccharide profiling for the detection of...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/34 (2006.01)

Patent

CA 2571332

The present invention provides methods for identifying oligosaccharides specific to cancer and methods for determining a strain of cancer in an individual. The present invention also provides methods for diagnosing cancer or a stage of cancer in an individual by detecting the presence or absence of specific cancer markers and methods for treating cancer by administering antibodies directed to such markers. In addition, the present invention provides cancer markers comprising O-linked oligosaccharides and kits for diagnosing or treating cancer.

L'invention concerne des procédés pour identifier des oligosaccharides spécifiques au cancer ainsi que des procédés pour déterminer une lignée de cancer chez un individu. L'invention concerne également des procédés pour diagnostiquer un cancer ou un stade cancéreux chez un individu par détection de la présence de l'absence de marqueurs cancéreux spécifiques, ainsi que des procédés pour traiter le cancer par administration d'anticorps dirigés contre de tels marqueurs. En outre, l'invention concerne des marqueurs cancéreux comprenant des oligosaccharides O-liés, ainsi que des kits pour le diagnostic ou le traitement du cancer.

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