C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C40B 30/04 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2757927
The present disclosure provides methods for assessing a patient's cancer risk and/or recurrence risk, which methods comprise assaying, in a biological sample obtained from the gastrointestinal (GI) tract of the patient, an expression level of a risk gene. The present disclosure also provides methods involving a cancer risk/recurrence risk sequence, i.e. the V600E mutation of the BRAF gene, which is useful for assessing cancer risk and/or recurrence risk in a patient.
Cette invention concerne des méthodes permettant d'évaluer le risque de survenue et/ou de récidive d'un cancer chez un patient, lesdites méthodes consistant à doser, dans un échantillon biologique prélevé dans le tractus gastro-intestinal (GI) du patient, le taux d'expression d'un gène indicateur de risque. L'invention concerne également des méthodes impliquant une séquence indicatrice du risque de survenue/récidive d'un cancer, à savoir la mutation V600E du gène BRAF, qui est utilisée pour évaluer le risque de survenue et/ou de récidive d'un cancer chez un patient.
Collin Francois
Cowens Wayne
Crager Michael
Cronin Maureen T.
Millward Carl L.
Genomic Health Inc.
Smart & Biggar
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