C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 251/50 (2006.01) C07D 209/48 (2006.01) C07D 213/30 (2006.01) C07D 215/54 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2608394
The present invention relates to methods for preparing substituted 3- cyanoquinolines and intermediates obtained by the methods of the present invention. The methods of the invention comprise reacting an N-aryl-2- propanimide with phosphoryl chloride to produce the substituted 3- cyanoquinolines. The methods further comprise reacting arylamines, orthoformates and active methylenes to produce the N-aryl-2-propenamide.
L'invention concerne des procédés de préparation de 3-cyanoquinoléines substituées et des intermédiaires obtenus au moyen des procédés selon l'invention. Ceux-ci consistent à faire réagir un N-aryl- 2-propanimide avec du chlorure de phosphoryle, de manière à produire les 3-cyanoquinoléines substituées. Les procédés consistent également à faire réagir des arylamines, des orthoformates et des méthylènes actifs aux fins de production du N-aryl-2-propénamide.
Chew Warren
Papamichelakis Maria
Torys Llp
Wyeth
LandOfFree
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