Methods of preparing quinoline derivatives

Details Methods of preparing quinoline derivatives Methods of preparing quinoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 215/22 (2006.01)

Patent

CA 2743416

A Method of preparing a compound of formula i(1) or a pharmaceutically acceptable salt thereof, wherein: R1 and R2 join together with the nitrogen atom to which they are attached form a 6 membered heterocycloalkyl X1 is H, Br, Cl or F; X2 is H, Br, Cl or F; s is 2-6; n1 is 1-2; and n2 is 1-2. The method comprising: contacting the compound of formula h(1) with reactant z(1) to yield the compound of formula i (1):

La présente invention concerne des procédés de préparation de composés de formule i(1) ou de sels pharmaceutiquement acceptables de ceux-ci, formule dans laquelle R1 et R2, conjointement avec l'atome d'azote auquel ils sont attachés, forment un groupe hétérocycloalkyle à 6 chaînons, X1 représente H, Br, Cl ou F, X2 représente H, Br, Cl ou F, s vaut de 2 à 6, n1 vaut 1 ou 2, et n2 vaut 1 ou 2.

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