Methods of preventing tissue damage associated with...

A - Human Necessities – 61 – K

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A61K 31/70 (2006.01) A61K 31/13 (2006.01) C07H 19/052 (2006.01)

Patent

CA 2096825

2096825 9306833 PCTABS00021 Methods of preventing tissue damage associated with decreased blood flow in a human by administering AICA riboside or a prodrug thereof in an amount which provides a blood plasma concentration of between 1 µg/ml and 20 µg/ml of AICA riboside for a time sufficient to reduce the risk of said tissue damage in said human. Methods of preventing an adverse clinical outcome, such as an adverse cardiovascular and/or cerebrovascular event, in a patient at risk for such outcome by administering AICA riboside or a prodrug thereof in an amount which provides a blood plasma concentration of between 1 µg/ml and 20 µg/ml of AICA riboside for a time sufficient to reduce the risk for said patient.

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