Methods of producing a terminally sterilized topical patch...

B - Operations – Transporting – 65 – B

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B65B 63/00 (2006.01) A61K 9/70 (2006.01) A61L 2/00 (2006.01) A61L 2/08 (2006.01) A61L 2/26 (2006.01) B65B 55/02 (2006.01) B65B 55/16 (2006.01)

Patent

CA 2403711

Methods of producing a terminally sterilized topical patch preparation are provided. In the subject methods, a topical patch preparation is exposed to electron beam radiation, preferably low level electron beam radiation, for a period of time sufficient to terminally sterilize the topical patch preparation. Also provided are the terminally sterilized topical patch preparations produced by the subject methods and methods of using the same.

L'invention concerne des procédés de production d'une préparation se présentant sous forme de timbre à application locale ayant subi une stérilisation terminale. Dans le procédé de l'invention, une préparation se présentant sous forme de timbre à application locale est exposée au rayonnement d'un faisceau électronique, de préférence au rayonnement d'un faisceau électronique de faible niveau, pendant suffisamment de temps pour que ladite préparation soit traitée par stérilisation terminale. L'invention porte également sur des préparations se présentant sous forme de timbre à application locale ayant subi une stérilisation terminale, produites par les procédés de l'invention et leurs procédés d'utilisation.

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