C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/078 (2010.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61P 7/00 (2006.01) C12N 5/02 (2006.01) C12N 5/18 (2006.01)
Patent
CA 2531360
The present invention generally provides methods for producing differentiated hematopoietic cells, including macrophages, platelets, and granulocytes, by adding cytokines to cultured synchronized bone marrow stem cells at specific phases of the cell cycle. The invention further provides differentiated hematopoietic cells produced by the methods of the invention, as well as methods for treating and/or preventing cytopenic states using the differentiated hematopoietic cells produces according to the methods of the invention.
L'invention concerne de façon générale des procédés de production de cellules hématopoïétiques différenciées, comprenant les macrophages, les plaquettes, ainsi que les granulocytes. Ces procédés consistent à ajouter des cytokines à des cellules souches de moelle osseuse synchronisées de culture à des phases spécifiques du cycle cellulaire. Par ailleurs, l'invention concerne des cellules hématopoïétiques différenciées obtenues par les procédés de l'invention, ainsi que des procédés de traitement et/ou de prévention des états de cytopénie au moyen des cellules hématopoïétiques différenciées obtenues selon les procédés de l'invention.
Borden Ladner Gervais Llp
Roger Williams Medical Center
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