Methods of producing esters of mycophenolate

Details Methods of producing esters of mycophenolate Methods of producing esters of mycophenolate

C - Chemistry, Metallurgy

12

P

C12P 17/16 (2006.01)

Patent

CA 2354554

Methods for the manufacture of Mycophenolate are disclosed. Mycophenolate mofetil is biochemically synthesized using Mycophenolic Acid and 2-morpholino ethanol with the help of an enzyme. Mycophenolate mofetil is also chemically synthesized non-catalytically by refluxing mycophenolic acid with 2-morpholino ethanol in the absence of a third solvent or a catalyst.

L'invention concerne des procédés de fabrication de mycophénolate, consistant à faire la synthèse biochimique du morpholinoéthylester de l'acide mycophilique (Mofétil), au moyen de l'acide mycophénolique et de 2-morpholino-éthanol, en présence d'une enzyme. On peut également faire la synthèse chimique du morpholinoéthylester de l'acide mycophilique (Mofétil), de façon non catalytique, en faisant bouillir à reflux de l'acide mycophénolique avec du 2-morpholino-éthanol, en l'absence d'un troisième solvant ou d'un catalyseur.

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