Methods of promoting osteogenesis

A - Human Necessities – 61 – K

Patent

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A61K 31/5377 (2006.01) A61K 31/00 (2006.01) A61K 31/136 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/4409 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/519 (2006.01) A61P 19/00 (2006.01)

Patent

CA 2497240

The invention is directed to methods of bone healing by administering a p38 MAP kinase inhibitor. The invention is directed to methods of treating bone fractures, bone diseases, bone grafting, especially enhancing bone healing following facial reconstruction, maxillary reconstruction, mandibular reconstruction or tooth extraction, enhancing long bone extension, enhancing prosthetic ingrowth, and increasing bone synostosis by administering a p38 MAP kinase inhibitor.

L'invention concerne des méthodes servant à cicatriser les os par administration d'un inhibiteur de kinase p38MAP. L'invention se rapporte à des méthodes de traitement de fractures osseuses, de maladies osseuses, de greffes osseuses. Ladite méthode permet d'améliorer, en particulier, la cicatrisation osseuse suivant la reconstruction faciale, la reconstruction maxillaire, la reconstruction mandibulaire ou l'extraction dentaire. Elle permet d'améliorer également l'extension de l'os long, l'interposition prothétique, la synostose osseuse par administration d'un inhibiteur de kinase p38MAP.

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