A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/57 (2006.01) A61K 36/42 (2006.01) A61K 36/81 (2006.01) A61K 38/08 (2006.01) A61P 3/04 (2006.01)
Patent
CA 2588087
The invention concerns a method of reducing body fat content of a subject in need thereof, the method comprising administering to the subject an agent capable of down-regulating activity and/or expression of at least one component participating in protein digestion and/or absorption. Such agents may be (i) an oligonucleotide directed to an endogenous nucleic acid sequence expressing said at least one component participating in said protein digestion and/or absorption or (ii) a protease inhibitor directed to said at least one component participating in protein digestion and/or absorption. The invention is particularly directed to a method of reducing body fat content of a subject in need thereof, the method comprising administering to the subject serine protease inhibitor inhibiting both enteropeptidase and trypsin activity.
Cette invention concerne un procédé servant à réduire la teneur en graisse corporelle chez un sujet nécessitant un tel traitement, ce procédé consistant à administrer audit sujet un agent capable d'abaisser l'activité et/ou l'expression d'au moins un composant participant à la digestion et/ou à l'absorption des protéines. De tels agents peuvent être: (i) un oligonucléotide dirigé sur une séquence d'acide nucléique endogène exprimant ce composant participant à la digestion et/ou à l'absorption des protéines; ou (ii) un inhibiteur de protéase dirigé sur ce composant participant à la digestion et/ou à l'absorption des protéines. Cette invention concerne en particulier un procédé servant à réduire la teneur en graisse corporelle chez un sujet nécessitant un tel traitement, ce procédé consistant à administrer audit sujet un inhibiteur de sérine protéase inhibant l'activité à la fois de l'entéropeptidase et de la trypsine.
Barradeau Sebastien
Fournes Benedicte
Harosh Itzik
Goudreau Gage Dubuc
Obe Therapy Biotechnology S.a.s.
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