Methods of reducing nephrotoxicity in subjects administered...

Details Methods of reducing nephrotoxicity in subjects administered... Methods of reducing nephrotoxicity in subjects administered...

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2685285

A conjugate compound comprising an acyclic nucleoside phosphonate covalently coupled to a lipid for the therapeutic and/or prophylactic treatment of viral infection in an immunodeficient subject is described, along with compositions and methods of using the same. A preferred conugate compound is CMX001, having formula (I) or a pharmaceutically acceptable salt thereof.

La présente invention concerne un composé conjugué comprenant un phosphonate de nucléoside acyclique couplé de manière covalente à un lipide pour le traitement thérapeutique et/ou prophylactique d'une infection virale chez un sujet immunodéficient, ainsi que des compositions et des procédés utilisant ce composé. Un composé conjugué préféré est CMX001, ayant la formule (I) ou l'un de ses sels acceptables sur le plan pharmaceutique.

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