Methods of reducing phosphate absorption

Details Methods of reducing phosphate absorption Methods of reducing phosphate absorption

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 13/12 (2006.01) C07K 16/02 (2006.01)

Patent

CA 2667524

A method for reducing phosphate absorption in a human or non-human animal subject at risk of developing or having developed hyperphosphatemia is disclosed. The method includes the step of administering orally to the subject an anti-intestinal sodium phosphate cotransporter type 2B (Npt2B) antibody in an amount effective to reduce or maintain the serum phosphate concentration in the subject.

L'invention concerne un procédé pour réduire l'absorption de phosphate chez un sujet humain ou animal, qui est à risque de développer ou ayant développé une hyperphosphatémie. Le procédé comprend l'étape consistant à administrer oralement au sujet un anticorps 2B (Npt2B) de type co-transporteur de phosphate de sodium anti-intestinal, en une quantité efficace pour réduire ou maintenir la concentration de phosphate sérique chez le sujet.

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