C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A01K 67/00 (2006.01) C07K 14/00 (2006.01) C12N 5/00 (2006.01) C12N 15/00 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2625169
Methods of avoiding repeat- and homology-induced silencing of transgenes are disclosed, in which trangene sequences are genetically altered to reduce the affects of gene silencing. FRET biosensors containing such genetic alterations for improved expression in cell lines and in vivo are disclosed.
L'invention concerne des méthodes permettant d'éviter l'extinction induite par des répétitions et des homologies de transgènes, dans lesquelles les séquences de transgènes sont génétiquement modifiées pour réduire les effets de l'extinction génique. L'invention concerne également des biocapteurs de transfert d'énergie de résonance par fluorescence (FRET) contenant ces modifications génétiques permettant une meilleure expression dans des lignées cellulaires et in vivo.
Deuschle Karen
Frommer Wolf B.
Barlow Charles Brian
Carnegie Institution Of Washington
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