Methods of reducing toxicity of chemotherapeutic and...

A - Human Necessities – 61 – K

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A61K 31/70 (2006.01) A61K 31/505 (2006.01) A61K 31/513 (2006.01) A61K 31/7068 (2006.01) A61K 31/7072 (2006.01) A61K 31/7115 (2006.01) A61K 31/712 (2006.01) A61P 35/00 (2006.01) C07D 237/02 (2006.01) C07D 239/00 (2006.01) C07H 19/067 (2006.01)

Patent

CA 2223640

The subject invention discloses compounds, compositions and methods for treatment and prevention of toxicity due to chemotherapeutic agents and antiviral agents. Disclosed are acylated derivatives of non-methylated pyrimidine nucleosides. These compounds are capable of attenuating damage to the hematopoietic system in animals receiving antiviral or antineoplastic chemotherapy.

La présente invention se rapporte à des composés, des compositions et des procédés de traitement et de prévention de la toxicité due à des agents chimiothérapeutiques et antiviraux. L'invention se rapporte également à des dérivés acylés de nucléosides de pyrimidine non méthylés. Ces composés peuvent atténuer les lésions du système hématopoïétique chez des animaux subissant une chimiothérapie antivirale ou antinéoplasique.

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