Methods of reduction of interpatient variability

Details Methods of reduction of interpatient variability Methods of reduction of interpatient variability

A - Human Necessities

61

K

A61K 31/13 (2006.01) A61K 31/404 (2006.01) A61K 31/4184 (2006.01) A61K 31/421 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2758588

Disclosed herein are methods for the reduction of inter-patient variability of a drug, such as in one or more parameters including half- life (t1/2), maximum plasma concentration (C max), time at maximal plasma concentration (T max), area under the time-versus-concentration curve (AUC). Also provided are methods of reducing side effects associated with drugs.

Les procédés selon l'invention permettent de réduire la variabilité d'un médicament d'un patient à l'autre, par exemple, au niveau d'un ou de plusieurs paramètres comprenant la demi-vie (t1/2), la concentration plasmatique maximale (Cmax), le temps à la concentration plasmatique maximale (Tmax), l'aire sous la courbe de concentration dans le temps (AUC). Des procédés permettant de réduire les effets secondaires associés auxdits médicaments sont également décrits.

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