C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/00 (2006.01) A61K 35/76 (2006.01) A61K 38/18 (2006.01) A61P 35/02 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2579764
The present invention provides methods of regulating cellular differentiation, including differentiation of stem cells and trans-differentiation of monocytes/macrophages using agonists or antagonists of pleiotrophin or a pleiotrophin receptor, as well as related methods of treating cancers associated with pleiotrophin-regulated differentiation and angiogenesis, including, e.g., multiple myeloma.
L'invention concerne des procédés pour réguler la différenciation cellulaire, y compris la différenciation de cellules souches et la transdifférenciation de monocytes/macrophages, au moyen d'agonistes ou d'antagonistes de pleiotrophine ou d'un récepteur de pleiotrophine. Cette invention se rapporte en outre à des procédés pour traiter des cancers associés à une différenciation régulée par la pleiotrophine et l'angiogenèse, y compris par ex. le myélome multiple.
Berenson James
Chen Haiming
Gordon Melinda S.
Borden Ladner Gervais Llp
Institute For Multiple Myeloma And Bone Cancer Research
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